Identification of Serum Soluble ST2 Receptor as a Novel Heart Failure Biomarker

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Identification of serum soluble ST2 receptor as a novel heart failure biomarker.

BACKGROUND Using genomic technology, we previously identified an interleukin-1 receptor family member, ST2, as a gene markedly induced by mechanical strain in cardiac myocytes. The soluble receptor form of ST2 is secreted and detectable in human serum. This study tested the hypothesis that soluble ST2 levels in the serum of patients with severe chronic heart failure are increased in patients wi...

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Soluble ST2: A Novel Prognostic Biomarker of Heart Failure.

Previous studies have demonstrated the role of ST2 in predicting hospitalization and mortality in heart failure, independent of natriuretic peptides and other clinical variables. 9-17 In 2011, the U.S. Food and Drug Administration (FDA) delared the Presage ST2 Assay (Critical Diagnostics, San Diego, California, USA), which is typically used in conjunction with clinical evaluation as an aid in a...

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Prognostic Value of Soluble ST2 (sST2) Serum Levels in Infants and Children with Heart Failure Complicating Congenital Heart Disease

Background Heart failure (HF) in infants and children with congenital heart disease (CHD) is a crucial complication with different outcomes. Many biomarkers are used as prognostic indicators. Soluble ST2 (sST2) is one of these markers studied in adults with HF. We aimed to study the prognostic value of sST2 in CHD children with HF. Materials and Methods In current case-control study, thirty-six...

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Serum soluble ST2 as a biochemical marker of acute heart failure: future areas of research.

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ژورنال

عنوان ژورنال: Circulation

سال: 2003

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.0000047274.66749.fe